The Science of HBV Cure Meeting 2021 ONLINE

11 to 15 October 2021


7:30 pm to 9:30 pm (SGT)

The Science of HBV Cure Meeting 2021 Online successfully concluded on 15 October, after 5 evenings of scientific updates from nineteen (19) Global Thought Leaders in Virology, Immunology and Clinical Science.  Ten (10) scientists presented their latest research on the Science of HBV Cure.

Please register or login to this site to watch Videos and download Slides of Presentations from our Global Thought Leader.


The Science of Functional Cure

7:30 pm – 9:30 pm (SGT)

Understanding immune mechanisms of HBV functional cure: a T cell perspective
– Dr. Carolina Boni
cccDNA silencing or elimination?
– Prof. Massimo Levrero
Intrahepatic Immunology – The key to Understanding CHB?
– Prof. Mala Maini
Free Paper: Role of anti-HBs in functional cure of HBeAg (+) CHB patients infected with genotype A
– Dr. Nadia Warner
Free Paper: Perspectives on immune regulatory mechanisms underlying the functional cure of CHB
– Dr. Narmada BC


Inhibiting Viral Replication

7:30 pm – 9:30 pm (SGT)

Discovery and Development of Novel Inhibitors of HBV Core Protein for the Treatment for CHB
– Dr. William Delaney
Entry Inhibitors for HBV/HDV
– Prof. Heiner Wedemeyer
Potential of HBV Capsid Assembly Modulators to Achieve Functional Cure
– Prof. Ju-Tao Guo
Free Paper: Preparation and characterisation of adjuvant loaded HBV capsids for therapeutic vaccine against CHB
– Dr. Jinpeng Su
Free Paper: Dual role of neddylation for transcription of HBV RNAs from cccDNA and expression of viral surface protein
– Dr. Bingqian Qu


Reduce Viral Antigen Burden

7:30 pm – 9:55 pm (SGT)

Clinical overview of AB-729, a potent siRNA in development for the treatment of chronic hepatitis B infection
– Dr. Gaston Picchio
HBV siRNA (RG6346): Significant & Durable reductions of HBsAg levels
– Dr. Cynthia Wat
Bepirovirsen Phase 2a Data Implying Potential Dual Mechanism of Action
– Dr. Shihyun You
Nucleic acid polymers: Biochemistry, molecular mechanism and application in the achievement of functional cure
– Prof. Andrew Valliant
The Potential of RNAi and NAPs
– Prof. Edward Gane
Free Paper: Phosphoproteome profiling unravels rewiring of host kinome and signalling pathways during early HBV infection
– Dr. Zijie Lim
Free Paper: Probing the spatiotemporal patterns of HBV multiplication reveals novel features of its subcellular processes
– Dr. Xiaonan Zhang


Immune Modulation in CHB

7:30 pm – 9:30 pm (SGT)

Toll-like Receptor 8 Agonist Selgantolimod for HBV Cure
– Dr Shahzada Khan
Innate immune modulators in HBV Cure
– Prof. Kumar Visvanathan
Adaptive Immunity in HBV infection
– Prof. Antonio Bertoletti
When and how to use immune modulators?
– Prof. Robert Thimme
Free Paper: Loss of HBsAg in CHB is associated with intra hepatic NK cell phenotype with enhanced activation status
– Dr. Sriram Narayanan
Free Paper: Intrahepatic T cell phenotypic characteristics in functionally cured patients
– Dr. Atefeh Khapoor


 The Future of  HBV Functional Cure

7:30 pm – 9:30 pm (SGT)

Debate: Functional cure can only be achieved with antiviral therapy For Against
– For: Prof. Pei-Jer Chen / Against: Dr. Adam Gehring
Hepatitis B Virus DNA Integration and Functional Cure
– Dr. Thomas Tu
What are the biomarkers as early response indicators?
– Prof. Marc Ghany
The strategies to achieve HBV functional cure
– Prof. Fabien Zoulim
Free Paper: HBV cccDNA is completely lost after mitosis of infected cells
– Dr. Thomas Tu
Free Paper: Identification and validation of HBx regulatory proteins
– Dr. Ramesh Kumar


Awareness Of HBV Among Undergraduate Students And Their Vaccination Status At Pakistani Medical University
– Dr. Jafferi Syed Khawar Abbas
Inspecting The Response Of Cells From The HepG2 Cell Line Against Hepatitis B Virus In The Investigation Of The Oxidative Stress Derived Transcription Factor Nrf-2 In The Tumor Microenviroment
– Mr. Rebanta Roy
Hepatitis B Recurrence In Liver Transplant Recipients: What Does It Mean?
– Dr. Ashwin Vinod
Recurrent HBV Infection Is Directly Associated With De Novo Malignancies In Liver Transplant Recipients
– Dr. Ashwin Vinod
The Value Of Acoustic Radiation Force Impulse Imaging For Evaluating Liver Fibrosis In Patients With Chronic Hepatitis B Infection
– Dr. Vo Huy Van
Increased Hepatic Pregnane X Receptor Protein Expression Negatively Correlates With Tight Junction Proteins In Patients With Hepatocellular Carcinoma
– Mr. Vairappan Balasubramaniyan
Seroprevalence Of Hepatitis B Virus And Hepatitis C Virus Among Blood Donors: Threats To Blood Safety
– Dr. Naveen Bansal
Anticancer Activity Of Annona Squamosa With Its Phytochemical Analysis By Liquid Chromatography Mass Spectroscopy
– Dr Shuchi Dave
Knowledge And Practices Related To Hepatitis B Virus (HBV) Infection Among Patients Belonging To A Rural
– Dr. Kritika Shrivastava
A Case Of Anicteric Hepatitis By Acute HBV Infection
– Dr. Ponkaj Naha