The Science of HBV Cure Meeting 2021 Online successfully concluded on 15 October, after 5 evenings of scientific updates from nineteen (19) Global Thought Leaders in Virology, Immunology and Clinical Science. Ten (10) scientists presented their latest research on the Science of HBV Cure.
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If you missed the HBV Cure Meeting 2021 Online or need a refresher, log in to this website to watch Videos and download Slides of Presentations from our Global Thought Leader.
11
Oct
The Science of Functional Cure
7:30 pm – 9:30 pm (SGT)
Understanding immune mechanisms of HBV functional cure: a T cell perspective
– Dr. Carolina Boni
cccDNA silencing or elimination?
– Prof. Massimo Levrero
Intrahepatic Immunology – The key to Understanding CHB?
– Prof. Mala Maini
Free Paper: Role of anti-HBs in functional cure of HBeAg (+) CHB patients infected with genotype A
– Dr. Nadia Warner
Free Paper: Perspectives on immune regulatory mechanisms underlying the functional cure of CHB
– Dr. Narmada BC
12
Oct
Inhibiting Viral Replication
7:30 pm – 9:30 pm (SGT)
Discovery and Development of Novel Inhibitors of HBV Core Protein for the Treatment for CHB
– Dr. William Delaney
Entry Inhibitors for HBV/HDV
– Prof. Heiner Wedemeyer
Potential of HBV Capsid Assembly Modulators to Achieve Functional Cure
– Prof. Ju-Tao Guo
Free Paper: Preparation and characterisation of adjuvant loaded HBV capsids for therapeutic vaccine against CHB
– Dr. Jinpeng Su
Free Paper: Dual role of neddylation for transcription of HBV RNAs from cccDNA and expression of viral surface protein
– Dr. Bingqian Qu
13
Oct
Reduce Viral Antigen Burden
7:30 pm – 9:55 pm (SGT)
Clinical overview of AB-729, a potent siRNA in development for the treatment of chronic hepatitis B infection
– Dr. Gaston Picchio
HBV siRNA (RG6346): Significant & Durable reductions of HBsAg levels
– Dr. Cynthia Wat
Bepirovirsen Phase 2a Data Implying Potential Dual Mechanism of Action
– Dr. Shihyun You
Nucleic acid polymers: Biochemistry, molecular mechanism and application in the achievement of functional cure
– Prof. Andrew Valliant
The Potential of RNAi and NAPs
– Prof. Edward Gane
Free Paper: Phosphoproteome profiling unravels rewiring of host kinome and signalling pathways during early HBV infection
– Dr. Zijie Lim
Free Paper: Probing the spatiotemporal patterns of HBV multiplication reveals novel features of its subcellular processes
– Dr. Xiaonan Zhang
14
Oct
Immune Modulation in CHB
7:30 pm – 9:30 pm (SGT)
Toll-like Receptor 8 Agonist Selgantolimod for HBV Cure
– Dr Shahzada Khan
Innate immune modulators in HBV Cure
– Prof. Kumar Visvanathan
Adaptive Immunity in HBV infection
– Prof. Antonio Bertoletti
When and how to use immune modulators?
– Prof. Robert Thimme
Free Paper: Loss of HBsAg in CHB is associated with intra hepatic NK cell phenotype with enhanced activation status
– Dr. Sriram Narayanan
Free Paper: Intrahepatic T cell phenotypic characteristics in functionally cured patients
– Dr. Atefeh Khapoor
15
Oct
The Future of HBV Functional Cure
7:30 pm – 9:30 pm (SGT)
